DPYD

DPYD is one of the key pharmacogenes involved in the implementation of pharmacogenomics.

• It is involved in guidelines for fluorouracil and capecitabine (go to list of all guidelines with DPYD).
• the nomenclature has been set by PharmVar
• the key variants are tier 1 DPYD c.1905+1G>A (*2A), DPYD c.1679T>G (*13), DPYD c.1129-5923C>G, c.1236G>A (HapB3), DPYD c.557A>G, DPYD c.868A>G, DPYD c.2279C>T, DPYD c.2846A>T , and tier 2 DPYD c.295_298delTCAT (*7), DPYD c.703C>T (*8), DPYD c.1314T>G, DPYD c.1475C>T, DPYD c.1774C>T,DPYD c.2639G>T [Article:39032821] see all alleles on the AMP recommended to test list.
• See the Gene-specific Information Tables for Allele Definitions (for which variants comprise which star alleles), Allele function assignments (normal function, no function, decreased or increased function etc) and Diplotype-Phenotype Table (for how the alleles combine to form metabolizer phenotypes for PM, NM, UM)