Disease:
Acquired Long QT Syndrome (aLQTS)

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Gene ? Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA No Variant Annotations available
rs10494366 106-38510G>T, 13574327G>T, 162085685G>T, 51105G>T
G > T
Intronic
No VIP available CA No Variant Annotations available
rs10918594 13519330C>G, 162030688C>G
C > G
Not Available
No VIP available No Clinical Annotations available VA
rs1805123 11241157T>G, 150645534T>G, 1670A>C, 2690A>C, 34481A>C, K897T, KCNH2:K897T, Lys557Thr, Lys897Thr
T > G
Missense
Lys557Thr
No VIP available CA No Variant Annotations available
rs4799915 16417741C>T, 34928639C>T, 370-26795G>A
C > T
Intronic
No VIP available CA No Variant Annotations available
rs4933824 189056T>G, 34623589T>G, 61-107358T>G, 823+183206T>G, 83819125T>G
T > G
Intronic
No VIP available CA No Variant Annotations available
rs7142881 13093548G>A, 32093548G>A, 382+24963G>A, 67958G>A, 94+24963G>A
G > A
Intronic
No VIP available CA No Variant Annotations available
rs993648 182455994C>T, 32665412C>T, 481+12570G>A, 582+12570G>A, 70841G>A
C > T
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names: 
PharmGKB Accession Id: PA447300

Curated Information ?

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
iloperidone
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
verapamil
Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
antiarrhythmics, class i and iii
No related diseases are available

Publications related to Acquired Long QT Syndrome (aLQTS): 23

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Enhanced sensitivity to drug-induced QT interval lengthening in patients with heart failure due to left ventricular systolic dysfunction. Journal of clinical pharmacology. 2012. Tisdale James E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes. The pharmacogenomics journal. 2012. Ramirez A H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Data-driven prediction of drug effects and interactions. Science translational medicine. 2012. Tatonetti Nicholas P, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Factors Affecting the Degree of QT Prolongation with Drug Challenge in a Large Cohort of Normal Volunteers. Heart rhythm : the official journal of the Heart Rhythm Society. 2011. Kannankeril Prince J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
KCNH2 pharmacogenomics summary. Pharmacogenetics and genomics. 2010. Oshiro Connie, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association study of antipsychotic-induced QTc interval prolongation. The pharmacogenomics journal. 2010. Aberg K, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Drug- and non-drug-associated QT interval prolongation. British journal of clinical pharmacology. 2010. van Noord Charlotte, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia. Molecular psychiatry. 2009. Volpi S, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation. Pharmacogenetics and genomics. 2009. van Noord Charlotte, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Aliskiren-induced QT interval prolongation. Southern medical journal. 2009. Peitz Gregory J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
hERG potassium channels and the structural basis of drug-induced arrhythmias. Chemical research in toxicology. 2008. Mitcheson John S. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study. Circulation. 2007. Newton-Cheh Christopher, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. 2007. Tay Joshua K X, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Drug-induced long QT and torsade de pointes: recent advances. Current opinion in cardiology. 2007. Kannankeril Prince J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
hERG potassium channels and cardiac arrhythmia. Nature. 2006. Sanguinetti Michael C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Common human SCN5A polymorphisms have altered electrophysiology when expressed in Q1077 splice variants. Heart rhythm : the official journal of the Heart Rhythm Society. 2005. Tan Bi-Hua, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Predictive in silico modeling for hERG channel blockers. Drug discovery today. 2005. Aronov Alex M. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG. Clinical science (London, England : 1979). 2004. Hayashi Kenshi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Drug-induced torsades de pointes and implications for drug development. Journal of cardiovascular electrophysiology. 2004. Fenichel Robert R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Drug-induced prolongation of the QT interval. The New England journal of medicine. 2004. Roden Dan M. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior. Journal of medicinal chemistry. 2003. Pearlstein Robert, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation. 2002. Yang Ping, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Polymorphisms in beta-adrenergic receptor genes in the acquired long QT syndrome. Journal of cardiovascular electrophysiology. 2002. Kanki Hideaki, et al. PubMed