Disease:
Asthma

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Gene ? Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA CYP2C19 *1 N/A N/A N/A
No VIP available No VIP available VA CYP2C19 *2 N/A N/A N/A
No VIP available No VIP available VA CYP2C19 *3 N/A N/A N/A
No VIP available No VIP available VA CYP2C19 *8 N/A N/A N/A
No VIP available No VIP available VA CYP2C19 *9 N/A N/A N/A
No VIP available CA VA
rs1029489 *1066A>G, 27316217A>G, 27376217A>G, 55967A>G
A > G
3' Flanking
No VIP available CA VA
rs1042713 148206440G>A, 148206440G>G, 46A>A, 46A>G, 46G>A, 5285A>A, 5285A>G, 9369367G>A, 9369367G>G, ADRB2:16Arg>Gly, ADRB2:Arg16Gly, ADRB2:Gly16Arg, Arg16, Arg16=
G > A
Missense
Arg16Gly
No VIP available No Clinical Annotations available VA
rs10511905 32338024A>G, 32348024A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs1059288 *1865T>C, -1067T>C, -1116T>C, 19318T>C, 33207672A>G, 33267672A>G, 4499912G>G, 4548998G>G, 4711486G>G, 4741416A>G
G > A
3' UTR
No VIP available CA VA
rs1110470 -151-4960G>A, -19+11086G>A, -308+11086G>A, -494+11086G>A, 16177G>A, 27276427G>A, 27336427G>A
G > A
Intronic
No VIP available CA VA
rs11252394 4180870G>A, 4240870G>A
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs1126510 *754T>C, 19392001A>G, 47123783A>G
A > G
3' UTR
No VIP available CA VA
rs1131882 15909C>T, 3535923G>A, 3595923G>A, 795C>T, Ile265=
G > A
Synonymous
Ile265Ile
No VIP available No Clinical Annotations available VA
rs115501901 *547C>T, 157108C>T, 16478800C>T, 46282708C>T
C > T
3' UTR
No VIP available CA VA
rs11587213 -237A>G, 12673517A>G, 161184875A>G, 20771A>G, 4789A>G
A > G
5' Flanking
No VIP available No Clinical Annotations available VA
rs116551936
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs11702779 22030530G>A, 36368659G>A, 57937C>T, 58+52480C>T
G > A
Intronic
No VIP available CA VA
rs119774 16026833C>T, 16086833C>T, 48400C>T, 49-14840C>T, MRP1, rs119774
C > T
Intronic
No VIP available CA VA
rs12422149 20189372G>A, 26546G>A, 503G>A, 74883577G>A, 869G>A, 935G>A, Arg168Gln, Arg290Gln, Arg312Gln, SLCO2B1:Arg312Gln, SLCO2B1:G935A
G > A
Missense
Arg168Gln
No VIP available No Clinical Annotations available VA
rs1353411 -166G>A, 33781101G>A, 5086G>A, 52781101G>A
G > A
5' UTR
No VIP available No Clinical Annotations available VA
rs1419555 125569441C>T, 63602284C>T
C > T
Not Available
No VIP available CA VA
rs1423515 32656903G>A, 82062544G>A
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs144315541 4131522G>A, 4191522G>A
G > A
Not Available
No VIP available CA VA
rs1522113 3671654G>A, 439-1799C>T, 56331771G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs1540339 10400632C>T, 277+1504G>A, 427+1504G>A, 46489G>A, 48257326C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs1544410 1024+283G>A, 10383141C>T, 1174+283G>A, 48239835C>T, 63980G>A, VDR: BsmI, VDR:BsmI
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs1663330 47443496A>G, 66443496A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs1663332 47444344C>T, 66444344C>T
C > T
Not Available
No VIP available CA VA
rs16851030 *424C>T, 203135452C>T, 54624094C>T
C > T
3' UTR
No VIP available No Clinical Annotations available VA
rs17495520 11451178C>T, 166639905C>T
C > T
Not Available
No VIP available No Clinical Annotations available VA
rs17701271 142711243C>A, 67258964C>A
C > A
Not Available
No VIP available CA VA
rs1805010 -253A>C, -253A>G, -253A>T, 178A>C, 178A>G, 178A>T, 223A>C, 223A>G, 223A>T, 27296203A>C, 27296203A>G, 27296203A>T, 27356203A>C, 27356203A>G, 27356203A>T, 35953A>C, 35953A>G, 35953A>T, Ile60Leu, Ile60Phe, Ile60Val, Ile75Leu, Ile75Phe, Ile75Val
A > T
A > C
A > G
5' UTR
Ile60Val
No VIP available CA VA
rs1876828 1065+310C>T, 1107+111C>T, 1194+111C>T, 43911525C>T, 54898C>T, 582+111C>T, 9185677C>T, 955985A>A, 987+111C>T, CRHR1:rs1876828
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs1876829 1065+228T>A, 1065+228T>C, 1065+228T>G, 1107+29T>A, 1107+29T>C, 1107+29T>G, 1194+29T>A, 1194+29T>C, 1194+29T>G, 43911443T>A, 43911443T>C, 43911443T>G, 54816T>A, 54816T>C, 54816T>G, 582+29T>A, 582+29T>C, 582+29T>G, 9185595T>A, 9185595T>C, 9185595T>G, 956067G>C, 956067G>G, 956067G>T, 987+29T>A, 987+29T>C, 987+29T>G
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs1876831 31-38C>T, 436-38C>T, 43907745C>T, 51118C>T, 556-38C>T, 643-38C>T, 9181897C>T, 959796A>A
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs2031920 (-1053)C>T (Rsa 1 c1>c2), -1055C>T, 135339845C>T, 3979C>T, 6573776C>T, CYP2E1(-1055)C>T, Rsa1
C > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs2069514 (-2964)G>A, 28338G>A, 3860G>A, 45828777G>A, 75038220G>A, CYP1A2*1C
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs2071888 14135C>G, 33212855G>C, 33272855G>C, 4505105C>C, 4554190C>C, 4716678C>C, 4746599G>C, 518C>G, 779C>G, Thr173Arg, Thr260Arg
C > G
Missense
Thr173Arg
No VIP available No Clinical Annotations available VA
rs2075797 -616C>G, 33780651C>G, 4636C>G, 52780651C>G
C > G
5' Flanking
No VIP available CA VA
rs2115819 246472A>G, 3546154A>G, 36461A>G, 432-6550A>G, 45901089A>G, rs2115819
A > G
Intronic
No VIP available CA VA
rs2228079 203098275T>G, 306T>G, 54586917T>G, Ala102=
T > G
Synonymous
Ala102Ala
No VIP available No Clinical Annotations available VA
rs2239179 10401072T>C, 277+1064A>G, 427+1064A>G, 46049A>G, 48257766T>C, VDR:rs2239179
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs2239185 10387865G>A, 48244559G>A, 59256C>T, 756-3968C>T, 906-3968C>T
G > A
Intronic
No VIP available CA VA
rs2239347 27299021A>C, 27359021A>C, 38+1082A>C, 38771A>C, 468+1082A>C, 513+1082A>C
A > C
Intronic
No VIP available No Clinical Annotations available VA
rs2240017 11085071C>G, 45810919C>G, 5310C>G, 99C>G, His33Gln, TBX21:H33Q
C > G
Missense
His33Gln
No VIP available CA VA
rs2243250 -589C>T, 132009154C>T, 40323026C>T, 4782C>T
C > T
5' Flanking
No VIP available CA VA
rs2267715 187+5444C>T, 229+5444C>T, 28633C>T, 30706087G>A, 30716087G>A, 310+5444C>T
G > A
Intronic
No VIP available CA VA
rs2284220 187+3428C>T, 229+3428C>T, 26617C>T, 30708103G>A, 30718103G>A, 310+3428C>T
G > A
Intronic
No VIP available CA VA
rs2305089 166579270C>T, 530G>A, 70748727C>T, 7862G>A, Gly177Asp
C > T
Missense
Gly177Asp
No VIP available No Clinical Annotations available VA
rs2306168 1025C>T, 1391C>T, 1457C>T, 20213377C>T, 50551C>T, 74907582C>T, SLCO2B1:C1457T, SLCO2B1:Ser486Phe, Ser342Phe, Ser464Phe, Ser486Phe
C > T
Missense
Ser342Phe
No VIP available No Clinical Annotations available VA
rs2427827 -59-285T>C, 10760453T>C, 159271811T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs242939 -285+1631C>A, -285+1631C>G, -285+1631C>T, 122-3142C>A, 122-3142C>G, 122-3142C>T, 241+1631C>A, 241+1631C>G, 241+1631C>T, 38952T>A, 38952T>G, 38952T>T, 43895579C>A, 43895579C>G, 43895579C>T, 9169731C>A, 9169731C>G, 9169731C>T, 971962A>A, 971962A>C, 971962A>T, CRHR1:rs242939
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs242941 -404-1310A>C, -404-1310A>G, -404-1310A>T, 122-1310A>C, 122-1310A>G, 122-1310A>T, 122-6202A>C, 122-6202A>G, 122-6202A>T, 35892C>C, 35892C>G, 35892C>T, 43892520A>C, 43892520A>G, 43892520A>T, 9166672A>C, 9166672A>G, 9166672A>T, 975003G>A, 975003G>C, 975003G>G, CRHR1:rs242941
G > T
Intronic
No VIP available CA VA
rs255100 -260-8T>A, 15812T>A, 30718908A>T, 30728908A>T, 91-8T>A
A > T
Intronic
No VIP available No Clinical Annotations available VA
rs2569190 -121-139T>C, -221-39T>C, -260T>C, 1175843A>G, 140012916A>G, 5371T>C
A > G
Intronic
No VIP available CA VA
rs2660845 -1400C>T, 58581859G>A, 96438553G>A, LTA4H, rs2660845
G > A
5' Flanking
No VIP available CA VA
rs2781659 131891820A>G, 2456A>G, 36061277A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs28364072 16748T>C, 359281A>G, 618+7T>C, 621+7T>C, 7755285A>G, FCER2:T2206C
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs2872507 3314915G>A, 38040763G>A
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs295114 -23+1399C>T, 201195602C>T, 51405020C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs295137 201150040C>T, 51359458C>T
C > T
Not Available
No VIP available CA VA
rs3024530 -18-820A>G, -307-820A>G, -493-820A>G, 27290687A>G, 27350687A>G, 30437A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs3213729 -14G>C, -214G>C, -48G>C, 54393246G>C, 73393246G>C
G > C
5' UTR
No VIP available No Clinical Annotations available VA
rs35599367 20493C>T, 37399159G>A, 522-191C>T, 99366316G>A, CYP3A4*22
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs3752120 -266G>A, 24820239C>T, 52552021C>T
C > T
5' UTR
No VIP available No Clinical Annotations available VA
rs3775291 111551795C>T, 1234C>T, 187004074C>T, 18766C>T, Leu412Phe, TLR3: L412F, TLR3: P412L
C > T
Missense
Leu412Phe
No VIP available No Clinical Annotations available VA
rs3782905 10409473G>C, 146+6584C>G, 296+6584C>G, 37648C>G, 48266167G>C
G > C
Intronic
No VIP available CA VA
rs37973 -1106G>A, 4503G>A, 7997876G>A, 8007876G>A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs3813867 -1295G>C, 135339605G>C, 3739G>C, 6573536G>C, CYP2E1(-1295)C>G
G > C
5' Flanking
No VIP available CA VA
rs3856806 12415557C>T, 12475557C>T, 1347C>T, 1431C>T, 151209C>T
C > T
Synonymous
His449His
No VIP available No Clinical Annotations available VA
rs4271002 -594G>C, 18248268G>C, 4514G>C, 6106414G>C, NAT2 -594G>C, NAT2(-9246)C>G
G > C
5' Flanking
No VIP available No Clinical Annotations available VA
rs4291 -262T>A, 26828346T>A, 4761T>A, 61554194T>A
T > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs4292 -115C>T, 26828493C>T, 4908C>T, 61554341C>T
C > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs499368 -422+272A>T, -57-1711A>T, -58+272A>T, 260920T>A, 320920T>A
T > A
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs518350 27657544C>T, 7048113C>T
C > T
Not Available
No VIP available No Clinical Annotations available VA
rs557881 259125A>G, 28T>C, 319125A>G, Cys10Arg
A > G
Missense
Cys10Arg
No VIP available No Clinical Annotations available VA
rs6002674 22084789T>C, 42694220T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs6962027 *922T>A, 136701935T>A, 153537T>A, 341+15606A>T, 74734778T>A
T > A
3' Flanking
No VIP available No Clinical Annotations available VA
rs6962291 1137+9085T>A, 1275+9085T>A, 139671117T>A, 1401+9085T>A, 197937T>A, 266740T>A, 933+9085T>A
T > A
Intronic
No VIP available CA VA
rs6988229 139884509C>T, 53158058C>T, 658+5484G>A
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs7142086 -1667C>T, -1701C>T, -1867C>T, 54391593C>T, 73391593C>T
C > T
5' Flanking
No VIP available CA VA
rs7160796 -209+1363G>C, -43+1363G>C, -9+1363G>C, 54394614G>C, 73394614G>C
G > C
Intronic
No VIP available CA VA
rs7179742 10853610A>G, 127-242T>C, 40063053A>G
A > G
Intronic
No VIP available CA VA
rs730012 -444A>C, 179220638A>C, 24031911A>C, 4653A>C, LTC4S, LTC4S: A-444C, LTC4S:-444C, rs730012
A > C
5' Flanking
No VIP available No Clinical Annotations available VA
rs731236 10382063A>G, 1056T>C, 1206T>C, 48238757A>G, 65058T>C, Ile352=, Ile402=, NM_000376.2:c.1056T>C, NP_001017535.1:p.Ile352Ile, NP_001017536.1:p.Ile402Ile, VDR: TaqI, VDR:Taq1 T>t
A > G
Synonymous
Ile402Ile
No VIP available No Clinical Annotations available VA
rs73294475 30691596T>C, 30701596T>C, 43124A>G, 716+176A>G, 755+176A>G, 758+176A>G, 839+176A>G
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs739645 -285+1042T>A, -285+1042T>C, -285+1042T>G, 122-3731T>A, 122-3731T>C, 122-3731T>G, 241+1042T>A, 241+1042T>C, 241+1042T>G, 38363T>A, 38363T>C, 38363T>G, 43894990T>A, 43894990T>C, 43894990T>G, 9169142T>A, 9169142T>C, 9169142T>G, 972552C>C, 972552C>G, 972552C>T
C > A
Intronic
No VIP available No Clinical Annotations available VA
rs74973995 524468A>G, 96962052A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs7543182 *24-21431G>T, 1078-21431G>T, 1105-21431G>T, 1309-4971G>T, 1336-4971G>T, 1336-8457G>T, 178519G>T, 41311891C>A, 71339973C>A
C > A
Intronic
No VIP available No Clinical Annotations available VA
rs7551789 -1478T>A, -1709T>A, 1259+298A>T, 3523T>A, 41486887A>T, 71514969A>T
A > T
5' Flanking
No VIP available CA VA
rs7572857 220G>A, 44118685G>A, 65296798G>A, Gly74Ser
G > A
Missense
Gly74Ser
No VIP available No Clinical Annotations available VA
rs77149876 121668T>C, 14025131T>C, 14085131T>C, 480-11761T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs77441273 1562G>A, 1697G>A, 1754G>A, 175933G>A, 73959857G>A, 92959857G>A, Arg521Gln, Arg566Gln, Arg585Gln
G > A
Missense
Arg585Gln
No VIP available CA VA
rs7793837 -166-546T>A, 17943T>A, 184+2030T>A, 30716777A>T, 30726777A>T, CRHR2: Intronic, downstream of exon beta 1b
A > T
Intronic
No VIP available No Clinical Annotations available VA
rs77977790 176695479T>C, 268173T>C, 28184121T>C, 3799-13283T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs8191725 -661T>C, 160429357A>G, 290-685A>G, 44227A>G, 64598814A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs8191992 *295T>A, 136701308T>A, 152910T>A, 341+16233A>T, 74734151T>A
T > A
3' UTR
No VIP available No Clinical Annotations available VA
rs881152 -600C>T, 17009828G>A, 172198555G>A, DUSP1 rs881152 G>A
G > A
5' Flanking
No VIP available CA VA
rs8832 *636A>G, 27315787A>G, 27375787A>G, 55537A>G
A > G
3' UTR
No VIP available No Clinical Annotations available VA
rs892940 24478838A>G, 24538838A>G, 2476T>C, 406-2185A>G
A > G
Intronic
No VIP available CA VA
rs9552679 23231920T>C, 4211920T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs959 *261A>G, *305A>G, 1759A>G, 1786A>G, 1855A>G, 200231A>G, 41290179T>C, 71318261T>C
T > C
Not Available
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names: 
Synonym
Airway hyperreactivity; Asthma NOS; Asthma unspecified; Asthma, Bronchial; Asthmas; Asthmas, Bronchial; Asthmatic; BHR - Bronchial hyperreactivity; Bronchial Asthma; Bronchial Asthmas; Bronchial asthma; Bronchial hyperreactivity; Bronchial hyperresponsiveness; Bronchial hypersensitivity; Hyperreactive airways disease
PharmGKB Accession Id: PA443450
External Vocabularies

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway - Transcription Regulation, Pharmacodynamics
    Model displaying genes which may be involved in the nuclear complex formed that regulates transcription in response to glucocorticoids.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this disease. To report a pathway, click here.

Curated Information ?

Curated Information ?

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
May Prevent
Contraindicated With
No related diseases are available

Publications related to Asthma: 189

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The Vitamin D Antenatal Asthma Reduction Trial (VDAART): Rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children. Contemporary clinical trials. 2014. Litonjua Augusto A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop. The Journal of allergy and clinical immunology. 2014. Bousquet Jean, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The genomic origins of asthma. Thorax. 2014. Sharma Sunita, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting beta2-agonists: results of the pacman cohort. Pharmacogenomics. 2013. Zuurhout Miranda Jl, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Vitamin D related genes in lung development and asthma pathogenesis. BMC medical genomics. 2013. Kho Alvin T, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans. Journal of clinical pharmacology. 2013. Kim Kyoung-Ah, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. The Journal of allergy and clinical immunology. 2013. Wu Ann Chen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Statin Exposure is Associated with Decreased Asthma-Related Emergency Department Visits and Oral Corticosteroid Use. American journal of respiratory and critical care medicine. 2013. Tse Sze Man, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. BMC medical genetics. 2013. Himes Blanca E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
A genome-wide association study of bronchodilator response in Latinos implicates rare variants. The Journal of allergy and clinical immunology. 2013. Drake Katherine A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association analysis of tapasin polymorphisms with aspirin-exacerbated respiratory disease in asthmatics. Pharmacogenetics and genomics. 2013. Cho Sung-Hwan, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of interactions in pharmacogenetic studies: leukotrienes in asthma. Pharmacogenomics. 2013. Via Marc, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16. Pulmonary pharmacology & therapeutics. 2013. Blake Kathryn, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Diagnostic accuracy of the bronchodilator response in children. The Journal of allergy and clinical immunology. 2013. Tse Sze Man, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association of CYP2C19 Polymorphisms and Lansoprazole-Associated Respiratory Adverse Effects in Children. The Journal of pediatrics. 2013. Lima John J, et al. PubMed
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A genome-wide association study of bronchodilator response in asthmatics. The pharmacogenomics journal. 2013. Duan Q L, et al. PubMed
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Fluticasone Propionate Pharmacogenetics: CYP3A4*22 Polymorphism and Pediatric Asthma Control. The Journal of pediatrics. 2013. Stockmann Chris, et al. PubMed
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HLA-DQ strikes again: Genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2012. Lasky-Su J, et al. PubMed
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Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort. Current respiratory care reports. 2012. Chipps Bradley E, et al. PubMed
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Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PloS one. 2013. Himes Blanca E, et al. PubMed
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Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. The Journal of allergy and clinical immunology. 2012. Myers Rachel A, et al. PubMed
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Tailored second line therapy in asthmatic children with the arginine-16 genotype. Clinical science (London, England : 1979). 2012. Lipworth Brian J, et al. PubMed
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Integrative systems biology approaches in asthma pharmacogenomics. Pharmacogenomics. 2012. Dahlin Amber, et al. PubMed
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Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma. The pharmacogenomics journal. 2012. Berce V, et al. PubMed
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IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor alpha antagonist. The Journal of allergy and clinical immunology. 2012. Slager Rebecca E, et al. PubMed
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Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. The Journal of allergy and clinical immunology. 2012. Chipps Bradley E, et al. PubMed
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The Effect of Vitamin D and Inhaled Corticosteroid Treatment on Lung Function in Children. American journal of respiratory and critical care medicine. 2012. Wu Ann Chen, et al. PubMed
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Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene. PLoS genetics. 2012. Himes Blanca E, et al. PubMed
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Genome-wide association study of the age of onset of childhood asthma. The Journal of allergy and clinical immunology. 2012. Forno Erick, et al. PubMed
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Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus. American journal of respiratory and critical care medicine. 2012. Tantisira Kelan G, et al. PubMed
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Genome-wide association analysis of circulating vitamin D levels in children with asthma. Human genetics. 2012. Lasky-Su Jessica, et al. PubMed
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Association between WDR21A polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients. Pharmacogenetics and genomics. 2012. Cho Sung-Hwan, et al. PubMed
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Very important pharmacogene summary for VDR. Pharmacogenetics and genomics. 2012. Poon Audrey H, et al. PubMed
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Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D. The Journal of allergy and clinical immunology. 2012. Tse Sze Man, et al. PubMed
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Predicting inhaled corticosteroid response in asthma with two associated SNPs. The pharmacogenomics journal. 2012. McGeachie M J, et al. PubMed
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PharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6. Pharmacogenetics and genomics. 2012. McDonagh Ellen M, et al. PubMed
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Resequencing candidate genes implicates rare variants in asthma susceptibility. American journal of human genetics. 2012. Torgerson Dara G, et al. PubMed
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Variation at GLCCI1 and FCER2: one step closer to personalized asthma treatment. Pharmacogenomics. 2012. Maitland-van der Zee Anke Hilse, et al. PubMed
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New approaches to personalized medicine for asthma: where are we?. The Journal of allergy and clinical immunology. 2012. Weiss Scott T. PubMed
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Pharmacogenetics of asthma controller treatment. The pharmacogenomics journal. 2012. Mougey E B, et al. PubMed
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A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. The pharmacogenomics journal. 2012. Duan Q L, et al. PubMed
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FCER2 T2206C variant associated with chronic symptoms and exacerbations in steroid-treated asthmatic children. Allergy. 2011. Koster E S, et al. PubMed
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Association of hypothalamic-pituitary-adrenal axis-related polymorphisms with stress in asthmatic children on inhaled corticosteroids. Neuroimmunomodulation. 2012. Tsartsali Lemonia, et al. PubMed
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Vitamin D in asthma and allergy: what next?. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2011. Weiss S T, et al. PubMed
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Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations. The Journal of allergy and clinical immunology. 2011. Du Rose, et al. PubMed
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CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma. Respiratory medicine. 2011. Perin Petra, et al. PubMed
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Genetic and histologic evidence for autophagy in asthma pathogenesis. The Journal of allergy and clinical immunology. 2011. Poon Audrey H, et al. PubMed
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The pharmacogenetics and pharmacogenomics of asthma therapy. The pharmacogenomics journal. 2011. Tse S M, et al. PubMed
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STAT6 links IL-4/IL-13 stimulation with pendrin expression in asthma and chronic obstructive pulmonary disease. Clinical pharmacology and therapeutics. 2011. Nofziger C, et al. PubMed
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Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. The New England journal of medicine. 2011. Tantisira Kelan G, et al. PubMed
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RUNX Transcription Factors: Association with Pediatric Asthma and Modulated by Maternal Smoking. American journal of physiology. Lung cellular and molecular physiology. 2011. Haley Kathleen J, et al. PubMed
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Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nature genetics. 2011. Hirota Tomomitsu, et al. PubMed
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Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nature genetics. 2011. Mexico City Childhood Asthma Study (MCAAS), et al. PubMed
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Genome Wide Association Study to Predict Severe Asthma Exacerbations in Children using Random Forests Classifiers. BMC medical genetics. 2011. Xu Mousheng, et al. PubMed
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Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-delta. The Journal of pharmacology and experimental therapeutics. 2011. Mercado Nicolas, et al. PubMed
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Role of Toll-like Receptor 3 Variants in Aspirin-Exacerbated Respiratory Disease. Allergy, asthma & immunology research. 2011. Palikhe Nami Shrestha, et al. PubMed
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Association of SERPINE2 with Asthma. Chest. 2011. Himes Blanca E, et al. PubMed
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Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients. Pharmacogenomics. 2011. Oh Sun-Hee, et al. PubMed
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Bacterial components plus vitamin D: The ultimate solution to the asthma (autoimmune disease) epidemic?. The Journal of allergy and clinical immunology. 2011. Weiss Scott T. PubMed
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Influence of gene-gene interactions on response to albuterol therapy. Pharmacogenomics. 2011. Moore Paul E. PubMed
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Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity. Pharmacogenetics and genomics. 2010. Kim Byung Soo, et al. PubMed
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Risk factors and predictive clinical scores for asthma exacerbations in childhood. Chest. 2010. Forno Erick, et al. PubMed
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PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenetics and genomics. 2010. Thorn Caroline F, et al. PubMed
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PDE11A associations with asthma: results of a genome-wide association scan. The Journal of allergy and clinical immunology. 2010. DeWan Andrew T, et al. PubMed
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Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients. The Journal of allergy and clinical immunology. 2010. Jin Ying, et al. PubMed
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In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma. The Journal of allergy and clinical immunology. 2010. Cohen Robyn T, et al. PubMed
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PharmGKB summary: cytochrome P450, family 2, subfamily J, polypeptide 2: CYP2J2. Pharmacogenetics and genomics. 2010. Berlin Dorit S, et al. PubMed
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Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population. Annals of human genetics. 2010. Pasaje Charisse Flerida A, et al. PubMed
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Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics. Pharmacogenomics. 2010. Kim Jin-Moo, et al. PubMed
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Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. The Journal of allergy and clinical immunology. 2010. Brehm John M, et al. PubMed
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What genes tell us about the pathogenesis of asthma and chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine. 2010. Weiss Scott T. PubMed
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Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics. BMB reports. 2010. Park Byung-Lae, et al. PubMed
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GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. Pharmacogenetics and genomics. 2010. Choudhry Shweta, et al. PubMed
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Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. American journal of respiratory and critical care medicine. 2010. Bleecker Eugene R, et al. PubMed
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Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP). Clinical pharmacology and therapeutics. 2010. Bain G, et al. PubMed
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Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. Pharmacogenetics and genomics. 2010. Vonk Judith M, et al. PubMed
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A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. American journal of respiratory and critical care medicine. 2010. Sharma Sunita, et al. PubMed
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Development of a Pharmacogenetic Predictive Test in asthma: proof of concept. Pharmacogenetics and genomics. 2010. Wu Ann Chen, et al. PubMed
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A genome-wide association study on African-ancestry populations for asthma. The Journal of allergy and clinical immunology. 2010. Mathias Rasika A, et al. PubMed
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Stronger evidence for replication of NPPA using genome-wide genotyping data. American journal of respiratory and critical care medicine. 2010. Rogers Angela J, et al. PubMed
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Very important pharmacogene summary ADRB2. Pharmacogenetics and genomics. 2010. Litonjua Augusto A, et al. PubMed
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Variants of DENND1B associated with asthma in children. The New England journal of medicine. 2010. Sleiman Patrick M A, et al. PubMed
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Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. BMC pulmonary medicine. 2010. Kim Jason Yongha, et al. PubMed
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Genome-wide and follow-up studies identify CEP68 gene variants associated with risk of aspirin-intolerant asthma. PloS one. 2010. Kim Jeong-Hyun, et al. PubMed
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Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol. The Journal of allergy and clinical immunology. 2009. Basu Kaninika, et al. PubMed
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MMP12, lung function, and COPD in high-risk populations. The New England journal of medicine. 2009. Hunninghake Gary M, et al. PubMed
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Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 2009. Wechsler Michael E, et al. PubMed
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Association analysis of peroxisome proliferator-activated receptors gamma gene polymorphisms with asprin hypersensitivity in asthmatics. Allergy, asthma & immunology research. 2009. Oh Sun-Hee, et al. PubMed
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Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. American journal of human genetics. 2009. Verlaan Dominique J, et al. PubMed
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Predicting response to short-acting bronchodilator medication using Bayesian networks. Pharmacogenomics. 2009. Himes Blanca E, et al. PubMed
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Genetics and pharmacogenetics of the leukotriene pathway. The Journal of allergy and clinical immunology. 2009. Tantisira Kelan G, et al. PubMed
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Impact of pharmacokinetics and pharmacogenetics on the efficacy of pranlukast in Japanese asthmatics. Respirology (Carlton, Vic.). 2009. Asano Koichiro, et al. PubMed
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PRKCA: a positional candidate gene for body mass index and asthma. American journal of human genetics. 2009. Murphy Amy, et al. PubMed
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Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma. Pharmacogenetics and genomics. 2009. Corvol Harriet, et al. PubMed
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Leukotriene pathway genetics and pharmacogenetics in allergy. Allergy. 2009. Duroudier N P, et al. PubMed
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Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. American journal of respiratory and critical care medicine. 2009. Rogers Angela J, et al. PubMed
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Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. American journal of human genetics. 2009. Himes Blanca E, et al. PubMed
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5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. Pharmacogenetics and genomics. 2009. Tantisira Kelan G, et al. PubMed
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Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. Pharmacogenetics and genomics. 2009. Mougey Edward B, et al. PubMed
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Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity. Pharmacogenomics. 2009. York Timothy P, et al. PubMed
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Acute and chronic lung function responses to salmeterol and salmeterol plus fluticasone propionate in relation to Arg16Gly beta(2)-adrenergic polymorphisms. Current medical research and opinion. 2009. Yancey Steven W, et al. PubMed
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Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature genetics. 2009. Gudbjartsson Daniel F, et al. PubMed
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Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. Respiratory medicine. 2009. Kim Sang-Heon, et al. PubMed
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Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD. Respirology (Carlton, Vic.). 2009. Kim Woo J, et al. PubMed
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Pharmacogenetics of asthma. Current opinion in pulmonary medicine. 2009. Lima John J, et al. PubMed
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Asthma and genes encoding components of the vitamin D pathway. Respiratory research. 2009. Bossé Yohan, et al. PubMed
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Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma. Respiratory research. 2009. Raby Benjamin A, et al. PubMed
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Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2008. Kim T-H, et al. PubMed
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Effect of 17q21 variants and smoking exposure in early-onset asthma. The New England journal of medicine. 2008. Bouzigon Emmanuelle, et al. PubMed
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ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. American journal of respiratory and critical care medicine. 2008. Litonjua Augusto A, et al. PubMed
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Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma. Pharmacogenetics and genomics. 2008. Tantisira Kelan G, et al. PubMed
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Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma. Respiratory medicine. 2008. Palikhe Nami Shrestha, et al. PubMed
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Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms. The Journal of allergy and clinical immunology. 2008. Dijkstra Antoon, et al. PubMed
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Influence of beta2-adrenoceptor polymorphisms on the response to chronic use of albuterol in asthmatic children. Pediatric pulmonology. 2008. Giubergia Verónica, et al. PubMed
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Association of IL-13 polymorphisms with leukotriene receptor antagonist drug responsiveness in Korean children with exercise-induced bronchoconstriction. Pharmacogenetics and genomics. 2008. Kang Mi-Jin, et al. PubMed
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Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. Pharmacogenetics and genomics. 2008. Poon Audrey H, et al. PubMed
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Pharmacogenetic response to albuterol among asthmatics. Pharmacogenomics. 2008. Corvol Harriet, et al. PubMed
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Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. The New England journal of medicine. 2008. Ober Carole, et al. PubMed
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Clinical consequences of ADRbeta2 polymorphisms. Pharmacogenomics. 2008. Hawkins Gregory A, et al. PubMed
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Analysis of high-affinity IgE receptor (FcepsilonR1) polymorphisms in patients with aspirin-intolerant chronic urticaria. Allergy and asthma proceedings : the official journal of regional and state allergy societies. 2008. Palikhe Nami, et al. PubMed
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Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet. 2007. Bleecker Eugene R, et al. PubMed
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FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma. The Journal of allergy and clinical immunology. 2007. Tantisira Kelan G, et al. PubMed
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Allele-specific targeting of microRNAs to HLA-G and risk of asthma. American journal of human genetics. 2007. Tan Zheng, et al. PubMed
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Association of IL4R gene polymorphisms with asthma in Chinese populations. Human mutation. 2007. Zhang Haibing, et al. PubMed
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Patient-reported adverse events under asthma therapy: a community pharmacy-based survey. Clinical pharmacology and therapeutics. 2007. Laforest L, et al. PubMed
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A functional CD86 polymorphism associated with asthma and related allergic disorders. Journal of medical genetics. 2007. Corydon Thomas Juhl, et al. PubMed
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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007. Moffatt Miriam F, et al. PubMed
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IRAK-M is involved in the pathogenesis of early-onset persistent asthma. American journal of human genetics. 2007. Balaci Lenuta, et al. PubMed
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PPARG locus haplotype variation and exacerbations in asthma. Clinical pharmacology and therapeutics. 2007. Palmer C N A, et al. PubMed
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CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. Pharmacogenomics. 2007. Kim Seung-Hyun, et al. PubMed
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Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Pharmacogenetics and genomics. 2007. Kim Sang-Heon, et al. PubMed
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Effects of supportive treatment such as antioxidant or leukotriene receptor antagonist drugs on inflammatory and respiratory parameters in asthma patients. Clinical pharmacology and therapeutics. 2007. Tug T, et al. PubMed
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Pharmacogenetics of the human beta-adrenergic receptors. The pharmacogenomics journal. 2007. Taylor M R G. PubMed
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Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol. Thorax. 2006. Palmer C N A, et al. PubMed
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Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. European journal of clinical pharmacology. 2006. Yoon Yeomin, et al. PubMed
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Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. American journal of respiratory and critical care medicine. 2006. Lima John J, et al. PubMed
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Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma. The Journal of allergy and clinical immunology. 2006. Bleecker Eugene R, et al. PubMed
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beta-Adrenergic receptor polymorphisms and response to salmeterol. American journal of respiratory and critical care medicine. 2006. Wechsler Michael E, et al. PubMed
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Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase. Cellular and molecular neurobiology. 2006. Weinshilboum Richard M. PubMed
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Overview of the pharmacogenetics of asthma treatment. The pharmacogenomics journal. 2006. Weiss S T, et al. PubMed
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CXCR3 polymorphisms associated with risk of asthma. Biochemical and biophysical research communications. 2005. Cheong Hyun Sub, et al. PubMed
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Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. American journal of epidemiology. 2005. Thakkinstian Ammarin, et al. PubMed
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Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2005. Kim S-H, et al. PubMed
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Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. The Journal of allergy and clinical immunology. 2005. Contopoulos-Ioannidis Despina G, et al. PubMed
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A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. The Journal of clinical investigation. 2005. Sun Chun-Xiao, et al. PubMed
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TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proceedings of the National Academy of Sciences of the United States of America. 2004. Tantisira Kelan G, et al. PubMed
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Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma. Respiratory research. 2005. Litonjua Augusto A, et al. PubMed
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. American journal of respiratory and critical care medicine. 2004. Raby Benjamin A, et al. PubMed
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Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. American journal of respiratory and critical care medicine. 2004. Poon Audrey H, et al. PubMed
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The IL12B gene is associated with asthma. American journal of human genetics. 2004. Randolph Adrienne G, et al. PubMed
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Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma. Pharmacogenetics. 2004. Fukai Hiromi, et al. PubMed
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A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. Pharmacogenetics. 2004. Pillai Sreekumar G, et al. PubMed
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Defining a link with asthma in mice congenitally deficient in eosinophils. Science (New York, N.Y.). 2004. Lee James J, et al. PubMed
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Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Human molecular genetics. 2004. Tantisira Kelan G, et al. PubMed
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ADRB2 polymorphisms and asthma susceptibility: transmission disequilibrium test and meta-analysis. International archives of allergy and immunology. 2004. Migita Ohsuke, et al. PubMed
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Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology. 2004. Hjoberg Josephine, et al. PubMed
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Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. American journal of respiratory and critical care medicine. 2004. Silverman Eric S, et al. PubMed
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ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. American journal of respiratory and critical care medicine. 2003. Lind Denise L, et al. PubMed
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Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 2004. Israel Elliot, et al. PubMed
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Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. The Journal of allergy and clinical immunology. 2003. Silverman Edwin K, et al. PubMed
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An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. Pharmacogenetics. 2003. Small Kersten M, et al. PubMed
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Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of clinical investigation. 2003. McGraw Dennis W, et al. PubMed
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Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels. American journal of respiratory and critical care medicine. 2003. Storm van's Gravesande Karin, et al. PubMed
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Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, attenuates allergen-specific tumour necrosis factor alpha production and nuclear factor kappa B nuclear translocation in peripheral blood monocytes from atopic asthmatics. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2003. Tomari S, et al. PubMed
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Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma. Clinical pharmacology and therapeutics. 2003. Obase Yasushi, et al. PubMed
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Salmeterol (Serevent) asthma trial halted early. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2003. Wooltorton Eric. PubMed
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Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. American journal of respiratory cell and molecular biology. 2002. Silverman Eric S, et al. PubMed
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DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma. American journal of respiratory and critical care medicine. 2002. Baron Rebecca M, et al. PubMed
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Sequence variants in the FcepsilonRI alpha chain gene. Journal of applied physiology (Bethesda, Md. : 1985). 2002. Shikanai Toshiki, et al. PubMed
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Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. 2002. Simon Amy R, et al. PubMed
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5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists. European journal of clinical pharmacology. 2002. Fowler Stephen J, et al. PubMed
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Pharmacogenetics of asthma. American journal of respiratory and critical care medicine. 2002. Palmer Lyle J, et al. PubMed
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Cloning and functional analysis of the mouse 5-lipoxygenase promoter. American journal of respiratory cell and molecular biology. 2002. Silverman Eric S, et al. PubMed
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Gene expression profiling in inflammatory airway disease associated with elevated adenosine. American journal of physiology. Lung cellular and molecular physiology. 2002. Banerjee Suman K, et al. PubMed
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Theoretical 3D model of histamine N-methyltransferase: insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability. Biochemical and biophysical research communications. 2001. Pang Y P, et al. PubMed
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The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). European journal of pharmacology. 2001. Green S A, et al. PubMed
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Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking. American journal of respiratory and critical care medicine. 2001. Wang Z, et al. PubMed
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Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. International archives of allergy and immunology. 2001. Israel E, et al. PubMed
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Airway wall remodelling and hyperresponsiveness: modelling remodelling in vitro and in vivo. Pulmonary pharmacology & therapeutics. 2001. Stewart A G. PubMed
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Heat shock proteins' mRNA expression in asthma. Respirology (Carlton, Vic.). 2000. Tong W, et al. PubMed
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Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism. Thorax. 2000. Taylor D R, et al. PubMed
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The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. American journal of respiratory and critical care medicine. 2000. Israel E, et al. PubMed
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Tolerance to beta-agonists during acute bronchoconstriction. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 1999. Hancox R J, et al. PubMed
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Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nature genetics. 1999. Drazen J M, et al. PubMed
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Estrogen acutely stimulates endothelial nitric oxide synthase in H441 human airway epithelial cells. American journal of respiratory cell and molecular biology. 1999. Kirsch E A, et al. PubMed
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Effects of gender and race on albuterol pharmacokinetics. Pharmacotherapy. 1999. Mohamed M H, et al. PubMed
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beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. American journal of respiratory and critical care medicine. 1998. Weir T D, et al. PubMed
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Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. The Journal of clinical investigation. 1997. Martinez F D, et al. PubMed
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Inhibition of interleukin-5 gene expression by dexamethasone. Immunology. 1992. Rolfe F G, et al. PubMed